GABA acting compounds [Stress & Sleep]
GABA (gamma-Aminobutyric acid) is the brain's main inhibitory neurotransmitter. Your body produces it from the amino acid L-Glutamate (also called L-Glutamic acid). It is involved in relaxation, stress response, sleep, focus, and various functions in the brain and body.
There are 4 main ways to effect GABA:
Precursors such as the amino acid L-Glutamic acid or a related amino acid analog L-Theanine (5-N-ethyl-glutamine) get converted into GABA.
Agonists such as Picamilon (nicotinoyl-GABA) and Phenibut (Beta-Phenyl-GABA) mimic and/or raise GABA levels in the brain. This class of compounds tend to be the most potent way to effect GABA.
Reuptake inhibitors are compounds that help prevent GABA from breaking down thus raising levels in the brain. HyperForin is a compound found in the plant St. John's Wort works via this pathway.
GABA-transaminase is the enzyme that breaksdown GABA. Inhibitors thus raise GABA levels.
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